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Fito M, Cladellas M, de la Torre R, Marti J, Alcantara M, Pujadas-Bastardes M, Marrugat J, Bruguera J, Lopez-Sabater MC, Vila J, Covas MI
Atherosclerosis. 2005 Jul;181(1):149-158. Epub 2005 Feb 12

12-07-2005
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Gli effetti antiossidanti dell’olio di oliva, ricco in composti fenolici, sono ben noti. Attraverso questo studio sono state messe a confronto le proprietà antiossidanti e antipertensive di due differenti tipi di olio, vergine e raffinato, differenti per contenuto di composti fenolici (14,7 mg/kg per l’olio raffinato e 161 mg/kg per quello vergine), su un campione di pazienti con cardiopatia stabile. L’assunzione di olio vergine ha prodotto una riduzione dei livelli di LDL ossidate, oltre ad una diminuzione della pressione sistolica nei pazienti ipertesi. Il consumo di olio vergine di oliva può quindi rappresentare un valido supporto alla terapia farmacologia nei pazienti cardiopatici.

Antioxidant effect of virgin olive oil in patients with stable coronary heart disease: a randomized, crossover, controlled, clinical trial

The Mediterranean diet, in which olive oil is the main source of fat, has been associated with a reduced incidence of coronary heart disease (CHD) and low blood pressure levels. Virgin olive oil (VOO), besides containing monounsaturated fat, is rich in phenolic compounds (PC) with antioxidant properties. The aim of this study was to examine the antioxidant and anti-hypertensive effect of two similar olive oils, but with differences in their PC (refined: 14.7mg/kg versus virgin: 161.0mg/kg), in 40 males with stable CHD. The study was a placebo controlled, crossover, randomized trial. A raw daily dose of 50mL of VOO and refined olive oil (ROO) were sequentially administered over two periods of 3 weeks, preceded by 2-week washout periods in which ROO was used. Lower plasma oxidized LDL (p<0.001) and="" lipid="" peroxide="" levels="" (p="0.003)," together="" with="" higher="" activities="" of="" glutathione="" peroxidase="" (p="0.033)," were="" observed="" after="" voo="" intervention.="" systolic="" blood="" pressure="" decreased="" after="" intake="" of="" voo="" (p="0.001)" in="" hypertensive="" patients.="" no="" changes="" were="" observed="" in="" diastolic="" blood="" pressure,="" glucose,="" lipids,="" and="" antibodies="" against="" oxidized="" ldl.="" consumption="" of="" voo,="" rich="" in="" pc,="" could="" provide="" beneficial="" effects="" in="" chd="" patients="" as="" an="" additional="" and="" complementary="" intervention="" to="" the="" pharmacological="">Stella 17ss Shoesazzurro Classico Mccartney Ellis TF51JulKc3

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